To investigate the role of DNA topoisomerases in transcription. we have studied global gene expression in Saccharomyces cerevisiae cells deficient for topoisomerases I and II and performed single-gene analyses to support our findings. The genome-wide studies show a general transcriptional down-regulation upon lack of the enzymes. which correlates with gene activity but not gene length. https://www.getpureroutine.com/mega-deal-natio-celebrate-eyeshadow-palette-online-amazing-offer/