Briefly introduced the status and related theories foundation of Theoretical Informatics (TI) and Systems Biology (SB). These two disciplines were compared and analyzed in the three aspects of the background. epistemological ap- proach. informational energy of open systems. https://www.spidertattooz.com/OPI-GelColor-The-Color-That-Keeps-On-Giving-0-5-oz-HPJ07-p22791/