Environmental or self-antigens and homotypic interactions bring about BCR and Toll-like receptor (TLR) signaling, amplifying the reaction of CLL cells to other indicators in the microenvironment and rising the activation of anti-apoptotic and proliferation pathways.31,32 Genomic studies have recognized recurrent mutations in genes regulating tumor mobile-microenvironment interactions,... https://carlm531muc9.glifeblog.com/profile